VIVA Education Webinar 01 July 2020 web


Pediatric Approach to Cancer Predisposition

Friday , 29 Jan 2021
09:00 A.M. - 10: 30 A.M. (Singapore UTC+8)



The VIVA Asia Education Webinar Series brings together regional delegates from developing countries to discuss treatment, data management, and evaluation of outcomes for paediatric solid tumours and leukaemia. This Webinar Series continues the educational opportunities offered by the VIVA Asia Educational Day, which evolved from the pre-forum workshop at the annual St. Jude-VIVA Forum in Paediatric Oncology.

Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. This session summarizes the current knowledge of cancer predisposition syndromes in pediatric oncology and provides essential information on clinical situations in which a childhood cancer predisposition syndrome should be suspected.


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        Dr Sharon Plon

Professor at Baylor College of Medicine


Dr. Sharon Plon is a board-certified medical geneticist and a longstanding cancer genetics researcher including leading to the discovery of new cancer susceptibility genes and the implementation of genomic testing in medicine.  Dr. Plon is a Professor at Baylor College of Medicine in the Departments of Pediatrics/Hematology-Oncology, Molecular and Human Genetics and Human Genome Sequencing Center. Drs. Plon and D. William Parsons were principal investigators of the NHGRI/NCI-funded BASIC3 clinical trial on the incorporation of exome sequencing into the care of newly diagnosed childhood cancer patients and this study is now being expanded into diverse patient populations across Texas (KidsCanSeq trial). Since 2013, Dr. Plon has served as one of the Principal Investigators of the Clinical Genome (ClinGen) Resource and chairs the ClinGen hereditary cancer effort. She currently co-chairs the germline reporting effort of the national NCI/COG Pediatric MATCH Precision Oncology trial. Dr. Plon is also working closely with Dr. Philip Lupo on a population-based study to understand the association between birth defects and cancer risk in children. Dr. Plon recently finished a three year term on the Board of Directors of the American Society of Human Genetics and is a member of the NIH Human Genome Research Advisory Council.



Dr Joanne Ngeow

Senior Consultant, Medical Oncology
Associate Professor (Genomic Medicine) - Lee Kong Chian School of Medicine, Nanyang Technological University
National Cancer Centre 

Dr Joanne Ngeow, BMedSci, MBBS, FRCP, MPH is Senior Consultant, Division of Medical Oncology at the National Cancer Centre Singapore and Associate Professor (Genomic Medicine) at the Lee Kong Chian School of Medicine, Nanyang Technological University Singapore. Dr Ngeow currently heads the Cancer Genetics Service at the National Cancer Centre Singapore with an academic clinical interest in hereditary cancer syndromes and translational clinical cancer genetics. Dr Ngeow is funded by the National Medical Research Council Clinician Scientist Award and Ministry of Health to explore how gene-environmental interactions predisposes to cancer initiation and progression and the implementation of genomics into routine clinical care. Dr Ngeow is one of the Principal Investigators of the Health for Life in Singapore Study (HELIOS), a state-of-the-art multi-ethnic population cohort study.


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Dr Soh Shui Yen

Head and Senior Consultant
Paediatric Haematology / Oncology Service
KK Women’s and Children’s Hospital


Dr Soh Shui-Yen is the Head and Senior Consultant from the Paediatric Haematology/Oncology Service of KK Women’s and Children’s Hospital (KKH) in Singapore. Dr Soh graduated from the Faculty of Medicine, National University of Singapore (NUS). She received her Paediatric Medicine training in Singapore and also completed 1 year of Paediatric Oncology clinical fellowship at the Hospital of Sick Children in Toronto, Canada. Her academic interests are in paediatric brain and solid tumours, as well as in cellular and immunotherapies in cancer. She is currently the Chair of the Paediatric Oncology Group Singapore and a steering committee member of the VIVA-KKH Paediatric Brain and Solid Tumour Programme. She also holds teaching appointments with the NUS Yong Loo Lin School of Medicine, the Duke-NUS Graduate School of Medicine, the National Technological University (NTU) – Lee Kong Chian (LKC) School of Medicine and the SingHealth Paediatrics Residency Programme.