Pubs

Doctors, researchers, and scientists are racing against the clock to find cures with less long-term side effects for kids with cancer. Here are some of the research published with leading, peer-reviewed medical journals by our partners funded under VIVA'S programmes, and by VIVA's alumni and partners.


VIVA External Advisory Committee

 

VIVA Alumni

 

VIVA-KKH Paediatric Brain and Solid Tumour Programme

     
  • Retroperitoneal tumors and congenital vascular anomalies of abdominal great vessels (2019)
    Tip SWM, Tang PH, Lee YT, Chang KTE, Soh SY, Tan AM, Loh AHP

    Journal of Paediatric Surgery
    Available from: http://dx.doi.org/10.1016/j.jpedsurg.2019.01.002

  • A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl (2019)
    Soon GST, Chang KTE, Kuick CH, Petersson F.

    Virchows Archiv 
    Available from: https://doi.org/10.1007/s00428-019-02524-w

  • Posterior retroperitoneoscopic adrenalectomy for pediatric adrenal tumors (2019)
    Lee YT, Samsudin H, Ong CCP, Tang PH, Lim KBL, Loh AHP

    Journal of Paediatric Surgery
    Available from: https://doi.org/10.1016/j.jpedsurg.2019.01.068

  • Primary adrenal angiomatoid fibrous histiocytoma with novel EWSR1-ATF1 gene fusion exon-exon breakpoint (2019)
    Khan IS, Kuick CH, Jain S, Lian DWQ, Loh AHP, Tan AM, Chang KTE

    Pediatric and Developmental Pathology
    Available from: https://doi.org/10.1177/1093526619830287

  • Primary paediatric epidural sarcomas: molecular exploration of three cases (2019) 
    Low SYY, Kuick CH, Seow WY, Bte Syed Sulaiman N, Chen H, Lian DWQ, Chang KTE, Tan EEK, Soh SY, Tan GIL, Ng LP, Seow WT, Low DCY
    BMC Cancer
    Available from: https://doi.org/10.1186/s12885-019-5368-z

  • A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour (2019) 
    Tan GIL, Merchant K, Tan EEK, Low DCY, Ng LP, Seow WT, Low SYY

    Child's Nervous System
    Available from: https://doi.org/10.1007/s00381-019-04128-w

  • Evaluation of a Novel Bony Landmark-Based Method for Teaching Percutaneous Insertion of Subclavian Venous Catheters in Pediatric Patients (2019)
    Lin ZJ, Lee YT, Chua JHY, Wang R, Lee V, Cheah SM, Saffari SE, Lam JCM, Loh AHP

    World Journal of Surgery
    Available from: https://doi.org/10.1007/s00268-019-04997-x

  • Glomus Tumor of the Kidney in a Child With Tuberous Sclerosis (2019)
    Zhao M, Yang, M, Gu W, Chen X, Chen H, Kuick CH, Chang KTE, Tang H.

    Pediatric and Developmental Pathology
    Available from: https://doi.org/10.1177%2F1093526619879601

  • Clear cell sarcoma of the kidney (2019)
    Aw SJ, Chang KTE

    Archives of Pathology and Laboratory Medicine 
    Available from: https://doi.org/10.5858/arpa.2018-0045-rs

  • Spindle cell tumour with S100 and CD34 co-expression showing PDZRN3-RAF1 rearrangement - a recently described entity (2019) 
    Mok YT, Kimpo MS, Chen HY, Kuick CH, Chang KTE, Lee VKM. Histopathology
    Available from: https://doi.org/10.1111/his.13841

  • Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations (2019)
    Loh AHP, Stewart E, Bradley CL, Chen X, Daryani V, Stewart CF, Calabrese C, Funk A, Miller G, Karlstrom A, Krafcik F, Goshorn DR, Vogel P, Bahrami A, Shelat A, Dyer MA.

    Cancer Letters
    Available from: https://doi.org/10.1016/j.canlet.2018.10.033

  • Clinical, pathological and loss of heterozygosity differences in Wilms tumors between Asian and non-Asian children (2019) 
    Loke BN, Wong MK, Tawng KD, Kuick CH, Jain S, Lian D, Wagner E, Zou Y, Ganesan V, Sim SW, Lee YT, Chin F, Chan MY, Tan AM, Teh BT, Soh SY, Chang KTE, Loh AHP
    International Journal of Cancer
    Available from: https://doi.org/10.1002/ijc.31946

  • Destined to Die: Apoptosis and Pediatric Cancers (2019)
    Choo Z, Loh AHP, Chen ZX

    Cancers (Basel)
    Available from: https://doi.org/10.3390/cancers11111623

  • Review.14. ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion (2019)
    Chang KTE, Tay A, Kuick CH, Chen HY, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, Chantranuwat C, Yuen ST, Chan JKC, Chow CW

    Modern Pathology
    Available from: https://doi.org/10.1038/s41379-018-0168-6

  • Intra-operative cerebrospinal fluid sampling versus post-operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours (2018)
    Low SYY, Wei CM, Chang KTE, Huak CY,Ping NL, Tew SW, et al.

    PLOS ONE
    Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196696

  • Neonatal orbital swelling due to intracranial teratoma (2019)
    Looi WS, Low DCY, Low SYY, et al. 

    Archives of Disease in Childhood - Fetal and Neonatal Edition
    Available from: https://doi.org/10.1136/archdischild-2018-316337

  • Primary Bone Anaplastic Large Cell Lymphoma Masquerading as Ewing Sarcoma: Diagnosis by Anchored Multiplex PCR (2018)
    Hue SS, Iyer P, Toh LHW, Jain S, Tan EEK, Sittampalam K, Lian DWQ, Chang KTE

    Journal of Pediatric Hematology/Oncology
    Available from: https://doi.org/10.1097/mph.0000000000000839

  • High‐grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features (2018)
    Mok Y, Agaimy A, Wang S, Kuick CH, Chang KT, Petersson F.
    Annals of Diagnostic Pathology
    https://doi.org/10.1016/j.anndiagpath.2018.09.004

  • ZC3H7B‐BCOR‐Rearranged Endometrial Stromal Sarcomas: A Distinct Subset Merits its Own Classification?  (2018)
    Mansor S, Kuick CH, Lim SL, Quek R, Wong APC, Lim‐Tan SK, Lim TYK, Chang KTE

    International Journal of Gynecological Pathology
    Available from: https://doi.org/10.1097/pgp.0000000000000523

  • TFE3‐Expressing Epithelioid Rich Perivascular Epithelioid Cell Neoplasm (PEComa) of the Bladder with Unusual Benign Course (2018)
    Chen XF, Yeong J, Chang KTE, Lim AST, Kuick CH, Lim TH, Sudhanshi J, Selvarajan S, Gan VHL, Khor LY

    Annals of Clinical and Laboratory Science
    Available from: http://www.annclinlabsci.org/content/48/1/110.full

  • A case of low grade fibromyxoid sarcoma with dedifferentiation. Pathology (2018)
    Tay TKY, Kuick CH, Lim TH, Chang KTE, Sittampalam KS
    Pathology
    Available from: https://doi.org/10.1016/j.pathol.2017.09.022

  • Primary Renal Hybrid Low‐grade Fibromyxoid Sarcoma‐Sclerosing Epithelioid Fibrosarcoma: An Unusual Pediatric Case With EWSR1‐CREB3L1 Fusion (2018)
    Mok Y, Pang YH, Sanjeev JS, Kuick CH, Chang KT

    Pediatric and Developmental Pathology
    Available from: https://doi.org/10.1177/1093526617754030

  • Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR‐CCNB3 gene fusion (2018)
    Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin M, Ma J, Zhang Z, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE

    Histopathology
    Available from: https://doi.org/10.1111/his.13366

  • Clinical Relevance of Screening Checklists for Detecting Cancer Predisposition Syndromes in Asian Childhood Tumours (2018)
    SH Chan, W Chew, ND Ishak, WK Lim, ST Li, SH Tan, JX Teo, T Shaw, K Chang, Y Chen, P Iyer, EEK Tan, MSF Seng, MY Chan, AM Tan, SYY Low, SY Soh, AHP Loh / J Ngeow. C.

    NPJ Genomic Medicine
    Available from: http://dx.doi.org/10.1038/s41525-018-0070-7

  • Intra‐ operative cerebrospinal fluid sampling versus post‐operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours (2018)
    Low SYY, Wei CM, Chang KTE, Huak CY, Ping NL, Tew SW, Low DCY

    PLOS ONE
    Available from: https://doi.org/10.1371/journal.pone.0196696
  • Development of a new patient‐derived xenograft humanised mouse model to study human‐ specific tumour microenvironment and immunotherapy (2018)
    Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q. 
    Gut
    Available from: https://doi.org/10.1136/gutjnl-2017-315201

  • Development and Evaluation of a Pan‐Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter Platform (2018)
    Chang KTE, Goytain A, Tucker T, Karsan A, Lee C‐H, Nielsen TO, Ng TL
    Journal of Molecular Diagnostics
    Available from: https://doi.org/10.1016/j.jmoldx.2017.09.007

  • Clinical, Pathological and Loss of Heterozygosity Differences in Wilms Tumors between Asian and non‐Asian Children (2018)
    Loke NB, Wong MK, Tawng KD, CH Kuick, S Jain, D Lian, E Wagner, YH Zou, V Ganesan, SW Sim, YT Lee, F Chin, MY Chan, AM Tan, BT Teh, SY Soh, KTE Chang, AHP Loh

    International Journal of Cancer
    Available from:  https://doi.org/10.1002/ijc.31946
  • Altano-axial subluxation with torticollis secondary to Langerhans cell histocytosis (2017)
    Joshua Y. Chua, Ji Min Ling, Derrick W.Q. Lian, Mei Yoke Chan, David C.Y. Low, Sharon Y.Y. Low.  2017 Dec; 10:101-103.

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
    Available from: http://dx.doi.org/10.1016/j.inat.2017.07.015

  • KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O 2- in a positive feedback mechanism in neuroblastoma (2017)
    Angelina, C., Tan, I.SY., Choo, Z., Lee, O.Z.J., Pervaiz, S., Chen, Z.X.

    Scientific Reports
    Available from: https://doi.org/10.1038/s41598-017-17192-6

  • Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel) (2017)
    Loke BN, Lee VKM, Sudhanshi J, Wong MK, Kuick CH, Puhaindran M, Chang KTE

    Journal of Clinical Pathology
    Available from: https://doi.org/10.1136/jclinpath-2016-204247

  • P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma (2016) 
    Bharathy N, Suriyamurthy S, Rao VK, Ow JR, Lim HJ, Chakraborty P, Vasudevan M, Dhamne CA, Chang KT, Min VL, Kundu TK, Taneja R.
    The Journal of Pathology
    Available from: https://doi.org/10.1002/path.4773

  • Wanted DEAD/H or Alive: Helicases Winding Up in Cancers (2017) 
    Cai W*, Chen ZX*, Rane G, Singh SS, Choo Z, Wang C, Yuan Y, Tan TZ, Arfuso F, Yap CT, Pongo LS, Yang H, Lee MB, Goh BC, Sethi G, Benoukraf T, Tergaonkar V, Kumar AP
    Journal of the National Cancer Institute
    Available from: https://doi.org/10.1093/jnci/djw278

  • Impact of subsidies on cancer genetic testing uptake in Singapore (2017)
    Li ST, Yuen J, Zhou K, Binte Ishak ND, Chen Y, Met-Domestici M, Chan SH, Tan YP, Allen JC Jr, Lim ST, Soo KC, Ngeow J.

    Journal of Medical Genetics
    Available from: http://dx.doi.org/10.1136/jmedgenet-2016-104302

  • VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma (2017)
    Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P.

    Cancer Discovery
    Available from: https://doi.org/10.1158/2159-8290.cd-17-0375

  • XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis (2016)
    Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX

    Oncotarget
    Available from: https://dx.doi.org/10.18632%2Foncotarget.8748
  • Post-operative diffusion weighted imaging as a predictor of posterior fossa syndrome permanence in paediatric medulloblastoma (2017)
    Chua FHZ, Thien A, Ng LP, Seow WT, Low DCY, Chang KTE, Lian DWQ, Loh E, Low SYY

    Child's Nervous System
    Available from: https://doi.org/10.1007/s00381-017-3356-7 

  • Anomalous intracranial germinoma with unilateral cerebral peduncle swelling (2017)
    Chua FHZ, Low DCY, Lian DWQ, Tew SW, Low SYY

    Childs Nervous System
    Available from: https://doi.org/10.1007/s00381-017-3355-8

  • Concurrent paediatric medulloblastoma and Chiari I malformation with syringomyelia (2017)
    Low SYY, Lian DWQ, Tang PH, Loh E, Seow WT, Low DCY

    Childs Nervous System
    Available from: https://doi.org/10.1007/s00381-017-3413-2

  • Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing (2017)
    Chew WHW, Courtney E, Lim KH, Li ST, Chen Y, Tan MH, Chung A, Khoo J, Loh A, Soh SY, Iyer P, Loh LM, Ngeow J

    Molecular Genetics & Genomic Medicine
    Available from: https://doi.org/10.1002/mgg3.313

  • Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel) (2017) 
    Loke BN, Lee VKM, Sudhanshi J, Wong MK, Kuick CH, Puhaindran M, Chang KT
    Journal of Clinical Pathology
    Available from: https://doi.org/10.1136/jclinpath-2016-204247

     

Mrs Lee Kong Chian Chair in Advanced Cellular Therapy

     

2020


2019

  • Engineering of natural killer cells for clinical application (2019)
    Shimasaki N, Campana D.
    In Methods in Molecular Biology, "Cell Reprogramming for Immunotherapy”, Rabinovitch P, Katz S eds., Springer
    Available from: http://dx.doi.org/10.1007/978-1-0716-0203-4_6

  • Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells (2019)
    Kamiya T, Seow SV, Wong D, Robinson M, Campana D. 
    Journal of Clinical Investigation
    Available from: https://doi.org/10.1172/jci123955


2018

  • A novel method to generate T cell receptor-deficient chimeric antigen receptor-T cells (2018)
    Kamiya T, Wong D, Png, YT, Campana D.
    Blood Advances
    Available from: https://doi.org/10.1182/bloodadvances.2017012823

  • A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression (2018)
    Makhija H, Roy S, Hoon S, Ghadessy F, Wong D; Jaiswal R, Campana D, Droge P.
    Nucleic Acids Research
    Available from: https://doi.org/10.1093/nar/gky500

2017

  • Blockade of CD7 expression in T cells for effective chimeric antigen-receptor targeting of T-cell malignancies (2017)
    Png YT, Vinanica N, Kamiya T, Shimasaki N, Coustan-Smith E, Campana D.
    Blood Advances
    Available from: https://dx.doi.org/10.1182/bloodadvances.2017009928

2016

  • Expanded and Armed NK cells for immunotherapy of cancer (2016)
    Shimasaki N, Kamiya T, Campana D.
    Cytotherapy
    Available from: https://doi.org/10.1016/j.jcyt.2016.06.013

  • NK cells maintain licensing status and are subject to KIR/KIR-ligand inhibition following ex vivo expansion (2016)
    Wang W, Erbe AK, Alderson KA, Phillips E, Gallenberger M, Gan J, Campana D, Hank JA, Sondel PM
    Cancer Immunology Research
    Availale from: https://dx.doi.org/10.1007%2Fs00262-016-1864-z

  • Expanded and activated natural killer cells for immunotherapy of hepatocellular carcinoma (2016)
    Kamiya T, Chang YH, Campana D. 
    Cancer Immunology Resesearch
    Available from: https://doi.org/10.1158/2326-6066.cir-15-0229
 

2015

2014

  • T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing (2014)
    Kudo K, Imai C, Lorenzini P, Kamiya T, Kono K, Davidoff AM, Chng WJ, Campana D. 
    Cancer Research
    Available from: https://doi.org/10.1158/0008-5472.can-13-1365

  • Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer (2014)
    Mimura K, Kamiya T, Shiraishi K, Kua LF, Shabbir A, So J, Yong WP, Suzuki Y, Yoshimito Y, Nakano T, Fujii H, Campana D, Kono K. International Journal of Cancer
    Available from: https://doi.org/10.1002/ijc.28780

  • Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15 (2014)
    Imamura M, Shook D, Kamiya T, Shimasaki N, Chai S, Coustan-Smith E, Imai C, Campana D.
    Blood
    Available from: https://doi.org/10.1182/blood-2014-02-556837

2013

  • A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells (2013)
    Chang YH, Connolly J, Shimasaki N, Mimura K, Kono K, Campana D. 
    Cancer Research
    Available from: https://doi.org/10.1158/0008-5472.can-12-3558

  • A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus (2013)
    Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, Soh AMO, Gehring AJ, Stauss H, Renia L, Sällberg M, Campana D, Bertoletti A.
    Molecular Therapy (Nucleic Acids)
    Available from: https://doi.org/10.1038/mtna.2013.43