Publications

VIVA External Advisory Committee

VIVA Alumni

• Developing leukemia protocols in cooperation between the Netherlands and Indonesia
  Veerman AJP et al.
  Pediatric Hematology Oncology Journal
  Available from: https://doi.org/10.1016/j.phoj.2020.03.007

• Survival of children with cancers amidst COVID-19: A fight with two enemies (2020)
  Bansal S, Dolendo M, Hoa Nguyen TK, Sharma K.
  Cancer Research Statistics and Treatment Online
  Available from: http://www.crstonline.com/text.asp?2020/3/2/281/287245

VIVA-NUS Centre for Translational Research in Acute Leukaemia (CenTRAL)

• Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study (2018)
  Yeoh AEJ, Lu Y, Chin WHN, et al.
  Journal of Clinical Oncology
  Available from: https://doi.org/10.1200/jco.2018.78.3050

• Universal monitoring of minimal residual disease in acute myeloid leukemia (2018)
  Coustan-Smith E, Song G, Shurtleff S, et al. . 
  JCI Insight
  Available from: https://doi.org/10.1172/jci.insight.98561

VIVA-KKH Paediatric Brain and Solid Tumour Programme

• Retroperitoneal tumors and congenital vascular anomalies of abdominal great vessels (2019)
  Tip SWM, Tang PH, Lee YT, Chang KTE, Soh SY, Tan AM, Loh AHP
  Journal of Paediatric Surgery
  Available from: http://dx.doi.org/10.1016/j.jpedsurg.2019.01.002
  
  
• A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl (2019)
  Soon GST, Chang KTE, Kuick CH, Petersson F.
  Virchows Archiv 
  Available from: https://doi.org/10.1007/s00428-019-02524-w
  
  
• Posterior retroperitoneoscopic adrenalectomy for pediatric adrenal tumors (2019)
  Lee YT, Samsudin H, Ong CCP, Tang PH, Lim KBL, Loh AHP
  Journal of Paediatric Surgery
  Available from: https://doi.org/10.1016/j.jpedsurg.2019.01.068
  
  
• Primary adrenal angiomatoid fibrous histiocytoma with novel EWSR1-ATF1 gene fusion exon-exon breakpoint (2019)
  Khan IS, Kuick CH, Jain S, Lian DWQ, Loh AHP, Tan AM, Chang KTE
  Pediatric and Developmental Pathology
  Available from: https://doi.org/10.1177/1093526619830287
  
  
• Primary paediatric epidural sarcomas: molecular exploration of three cases (2019) 
  Low SYY, Kuick CH, Seow WY, Bte Syed Sulaiman N, Chen H, Lian DWQ, Chang KTE, Tan EEK, Soh SY, Tan GIL, Ng LP, Seow WT, Low DCY
  BMC Cancer
  Available from: https://doi.org/10.1186/s12885-019-5368-z
  
  
• A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour (2019) 
  Tan GIL, Merchant K, Tan EEK, Low DCY, Ng LP, Seow WT, Low SYY
  Child's Nervous System
  Available from: https://doi.org/10.1007/s00381-019-04128-w
  
  
• Evaluation of a Novel Bony Landmark-Based Method for Teaching Percutaneous Insertion of Subclavian Venous Catheters in Pediatric Patients (2019)
  Lin ZJ, Lee YT, Chua JHY, Wang R, Lee V, Cheah SM, Saffari SE, Lam JCM, Loh AHP
  World Journal of Surgery
  Available from: https://doi.org/10.1007/s00268-019-04997-x
  
  
• Glomus Tumor of the Kidney in a Child With Tuberous Sclerosis (2019)
  Zhao M, Yang, M, Gu W, Chen X, Chen H, Kuick CH, Chang KTE, Tang H.
  Pediatric and Developmental Pathology
  Available from: https://doi.org/10.1177%2F1093526619879601
  
  
• Clear cell sarcoma of the kidney (2019)
  Aw SJ, Chang KTE
  Archives of Pathology and Laboratory Medicine 
  Available from: https://doi.org/10.5858/arpa.2018-0045-rs
  
  
• Spindle cell tumour with S100 and CD34 co-expression showing PDZRN3-RAF1 rearrangement - a recently described entity (2019) 
  Mok YT, Kimpo MS, Chen HY, Kuick CH, Chang KTE, Lee VKM. Histopathology
  Available from: https://doi.org/10.1111/his.13841
  
  
• Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations (2019)
  Loh AHP, Stewart E, Bradley CL, Chen X, Daryani V, Stewart CF, Calabrese C, Funk A, Miller G, Karlstrom A, Krafcik F, Goshorn DR, Vogel P, Bahrami A, Shelat A, Dyer MA.
  Cancer Letters
  Available from: https://doi.org/10.1016/j.canlet.2018.10.033
  
  
• Clinical, pathological and loss of heterozygosity differences in Wilms tumors between Asian and non-Asian children (2019) 
  Loke BN, Wong MK, Tawng KD, Kuick CH, Jain S, Lian D, Wagner E, Zou Y, Ganesan V, Sim SW, Lee YT, Chin F, Chan MY, Tan AM, Teh BT, Soh SY, Chang KTE, Loh AHP
  International Journal of Cancer
  Available from: https://doi.org/10.1002/ijc.31946
  
  
• Destined to Die: Apoptosis and Pediatric Cancers (2019)
  Choo Z, Loh AHP, Chen ZX
  Cancers (Basel)
  Available from: https://doi.org/10.3390/cancers11111623
  
  
• Review.14. ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion (2019)
  Chang KTE, Tay A, Kuick CH, Chen HY, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, Chantranuwat C, Yuen ST, Chan JKC, Chow CW
  Modern Pathology
  Available from: https://doi.org/10.1038/s41379-018-0168-6
  
  
• Intra-operative cerebrospinal fluid sampling versus post-operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours (2018)
  Low SYY, Wei CM, Chang KTE, Huak CY,Ping NL, Tew SW, et al.
  PLOS ONE
  Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196696
  
  
• Neonatal orbital swelling due to intracranial teratoma (2019)
  Looi WS, Low DCY, Low SYY, et al. 
  

  Archives of Disease in Childhood - Fetal and Neonatal Edition
  Available from: https://doi.org/10.1136/archdischild-2018-316337
  

• Primary Bone Anaplastic Large Cell Lymphoma Masquerading as Ewing Sarcoma: Diagnosis by Anchored Multiplex PCR (2018)
  Hue SS, Iyer P, Toh LHW, Jain S, Tan EEK, Sittampalam K, Lian DWQ, Chang KTE
  Journal of Pediatric Hematology/Oncology
  Available from: https://doi.org/10.1097/mph.0000000000000839
  

• High‐grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features (2018)
  Mok Y, Agaimy A, Wang S, Kuick CH, Chang KT, Petersson F.
  Annals of Diagnostic Pathology
  https://doi.org/10.1016/j.anndiagpath.2018.09.004

• ZC3H7B‐BCOR‐Rearranged Endometrial Stromal Sarcomas: A Distinct Subset Merits its Own Classification?  (2018)
  Mansor S, Kuick CH, Lim SL, Quek R, Wong APC, Lim‐Tan SK, Lim TYK, Chang KTE
  International Journal of Gynecological Pathology
  Available from: https://doi.org/10.1097/pgp.0000000000000523

• TFE3‐Expressing Epithelioid Rich Perivascular Epithelioid Cell Neoplasm (PEComa) of the Bladder with Unusual Benign Course (2018)
  Chen XF, Yeong J, Chang KTE, Lim AST, Kuick CH, Lim TH, Sudhanshi J, Selvarajan S, Gan VHL, Khor LY
  Annals of Clinical and Laboratory Science
  Available from: http://www.annclinlabsci.org/content/48/1/110.full

• A case of low grade fibromyxoid sarcoma with dedifferentiation. Pathology (2018)
  Tay TKY, Kuick CH, Lim TH, Chang KTE, Sittampalam KS
  Pathology
  Available from: https://doi.org/10.1016/j.pathol.2017.09.022
  
  
• Primary Renal Hybrid Low‐grade Fibromyxoid Sarcoma‐Sclerosing Epithelioid Fibrosarcoma: An Unusual Pediatric Case With EWSR1‐CREB3L1 Fusion (2018)
  Mok Y, Pang YH, Sanjeev JS, Kuick CH, Chang KT
  Pediatric and Developmental Pathology
  Available from: https://doi.org/10.1177/1093526617754030
  
  
• Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR‐CCNB3 gene fusion (2018)
  Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin M, Ma J, Zhang Z, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE
  Histopathology
  Available from: https://doi.org/10.1111/his.13366
  
  
• Clinical Relevance of Screening Checklists for Detecting Cancer Predisposition Syndromes in Asian Childhood Tumours (2018)
  SH Chan, W Chew, ND Ishak, WK Lim, ST Li, SH Tan, JX Teo, T Shaw, K Chang, Y Chen, P Iyer, EEK Tan, MSF Seng, MY Chan, AM Tan, SYY Low, SY Soh, AHP Loh / J Ngeow. C.
  NPJ Genomic Medicine
  Available from: http://dx.doi.org/10.1038/s41525-018-0070-7
  
  
• Intra‐ operative cerebrospinal fluid sampling versus post‐operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours (2018)
  Low SYY, Wei CM, Chang KTE, Huak CY, Ping NL, Tew SW, Low DCY
  PLOS ONE
  Available from: https://doi.org/10.1371/journal.pone.0196696

• Development of a new patient‐derived xenograft humanised mouse model to study human‐ specific tumour microenvironment and immunotherapy (2018)
  Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q. 
  Gut
  Available from: https://doi.org/10.1136/gutjnl-2017-315201
  
  
• Development and Evaluation of a Pan‐Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter Platform (2018)
  Chang KTE, Goytain A, Tucker T, Karsan A, Lee C‐H, Nielsen TO, Ng TL
  Journal of Molecular Diagnostics
  Available from: https://doi.org/10.1016/j.jmoldx.2017.09.007
  
  
• Clinical, Pathological and Loss of Heterozygosity Differences in Wilms Tumors between Asian and non‐Asian Children (2018)
  Loke NB, Wong MK, Tawng KD, CH Kuick, S Jain, D Lian, E Wagner, YH Zou, V Ganesan, SW Sim, YT Lee, F Chin, MY Chan, AM Tan, BT Teh, SY Soh, KTE Chang, AHP Loh
  International Journal of Cancer
  Available from:  https://doi.org/10.1002/ijc.31946
  

• Altano-axial subluxation with torticollis secondary to Langerhans cell histocytosis (2017)
  Joshua Y. Chua, Ji Min Ling, Derrick W.Q. Lian, Mei Yoke Chan, David C.Y. Low, Sharon Y.Y. Low.  2017 Dec; 10:101-103.
  Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
  Available from: http://dx.doi.org/10.1016/j.inat.2017.07.015
  
  
• KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O 2- in a positive feedback mechanism in neuroblastoma (2017)
  Angelina, C., Tan, I.SY., Choo, Z., Lee, O.Z.J., Pervaiz, S., Chen, Z.X.
  Scientific Reports
  Available from: https://doi.org/10.1038/s41598-017-17192-6
  
  
• Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel) (2017)
  Loke BN, Lee VKM, Sudhanshi J, Wong MK, Kuick CH, Puhaindran M, Chang KTE
  Journal of Clinical Pathology
  Available from: https://doi.org/10.1136/jclinpath-2016-204247
  
  

• P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma (2016) 
  Bharathy N, Suriyamurthy S, Rao VK, Ow JR, Lim HJ, Chakraborty P, Vasudevan M, Dhamne CA, Chang KT, Min VL, Kundu TK, Taneja R.
  The Journal of Pathology
  Available from: https://doi.org/10.1002/path.4773
  
  
• Wanted DEAD/H or Alive: Helicases Winding Up in Cancers (2017) 
  Cai W*, Chen ZX*, Rane G, Singh SS, Choo Z, Wang C, Yuan Y, Tan TZ, Arfuso F, Yap CT, Pongo LS, Yang H, Lee MB, Goh BC, Sethi G, Benoukraf T, Tergaonkar V, Kumar AP
  Journal of the National Cancer Institute
  Available from: https://doi.org/10.1093/jnci/djw278
  
  
• Impact of subsidies on cancer genetic testing uptake in Singapore (2017)
  Li ST, Yuen J, Zhou K, Binte Ishak ND, Chen Y, Met-Domestici M, Chan SH, Tan YP, Allen JC Jr, Lim ST, Soo KC, Ngeow J.
  Journal of Medical Genetics
  Available from: http://dx.doi.org/10.1136/jmedgenet-2016-104302
  
  
• VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma (2017)
  Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P.
  Cancer Discovery
  Available from: https://doi.org/10.1158/2159-8290.cd-17-0375
  
  
• XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis (2016)
  Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX
  Oncotarget
  Available from: https://dx.doi.org/10.18632%2Foncotarget.8748
  

• Post-operative diffusion weighted imaging as a predictor of posterior fossa syndrome permanence in paediatric medulloblastoma (2017)
  Chua FHZ, Thien A, Ng LP, Seow WT, Low DCY, Chang KTE, Lian DWQ, Loh E, Low SYY
  Child's Nervous System
  Available from: https://doi.org/10.1007/s00381-017-3356-7 
  
  
• Anomalous intracranial germinoma with unilateral cerebral peduncle swelling (2017)
  Chua FHZ, Low DCY, Lian DWQ, Tew SW, Low SYY
  Childs Nervous System
  Available from: https://doi.org/10.1007/s00381-017-3355-8
  
  
• Concurrent paediatric medulloblastoma and Chiari I malformation with syringomyelia (2017)
  Low SYY, Lian DWQ, Tang PH, Loh E, Seow WT, Low DCY
  Childs Nervous System
  Available from: https://doi.org/10.1007/s00381-017-3413-2
  
  
• Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing (2017)
  Chew WHW, Courtney E, Lim KH, Li ST, Chen Y, Tan MH, Chung A, Khoo J, Loh A, Soh SY, Iyer P, Loh LM, Ngeow J
  Molecular Genetics & Genomic Medicine
  Available from: https://doi.org/10.1002/mgg3.313
  
  
• Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel) (2017) 
  Loke BN, Lee VKM, Sudhanshi J, Wong MK, Kuick CH, Puhaindran M, Chang KT
  Journal of Clinical Pathology
  Available from: https://doi.org/10.1136/jclinpath-2016-204247

Mrs Lee Kong Chian Chair in Advanced Cellular Therapy

2020

• Specific stimulation of T lymphocytes with erythropoietin for adoptive immunotherapy
  Vinanica N, Yong A, Wong D, Png YT, Seow SV, Imamura M, Campana D. .
  Blood 
  Available from: https://doi.org/10.1182/blood.2019001645
  
  
• Infusion of natural killer cells for cancer immunotherapy (2020)
  Shimasaki N, Jain A, Campana D.
  Nature Reviews Drug Discovery
  Available from: http://dx.doi.org/10.1038/s41573-019-0052-1
  
  
• D. Chimeric antigen receptor-T cells with cytokine neutralizing capacity (2020)
  Tan AHJ, Vinanica N, Campana
  Blood Advances
  Available from: https://doi.org/10.1182/bloodadvances.2019001287

2019

• Engineering of natural killer cells for clinical application (2019)
  Shimasaki N, Campana D.
  In Methods in Molecular Biology, "Cell Reprogramming for Immunotherapy”, Rabinovitch P, Katz S eds., Springer
  Available from: http://dx.doi.org/10.1007/978-1-0716-0203-4_6
  
  
• Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells (2019)
  Kamiya T, Seow SV, Wong D, Robinson M, Campana D. 
  Journal of Clinical Investigation
  Available from: https://doi.org/10.1172/jci123955

2018

• A novel method to generate T cell receptor-deficient chimeric antigen receptor-T cells (2018)
  Kamiya T, Wong D, Png, YT, Campana D.
  Blood Advances
  Available from: https://doi.org/10.1182/bloodadvances.2017012823
  
  
• A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression (2018)
  Makhija H, Roy S, Hoon S, Ghadessy F, Wong D; Jaiswal R, Campana D, Droge P.
  Nucleic Acids Research
  Available from: https://doi.org/10.1093/nar/gky500
  
  

2017

• Blockade of CD7 expression in T cells for effective chimeric antigen-receptor targeting of T-cell malignancies (2017)
  Png YT, Vinanica N, Kamiya T, Shimasaki N, Coustan-Smith E, Campana D.
  Blood Advances
  Available from: https://dx.doi.org/10.1182/bloodadvances.2017009928
  
  

2016

• Expanded and Armed NK cells for immunotherapy of cancer (2016)
  Shimasaki N, Kamiya T, Campana D.
  Cytotherapy
  Available from: https://doi.org/10.1016/j.jcyt.2016.06.013
  
  
• NK cells maintain licensing status and are subject to KIR/KIR-ligand inhibition following ex vivo expansion (2016)
  Wang W, Erbe AK, Alderson KA, Phillips E, Gallenberger M, Gan J, Campana D, Hank JA, Sondel PM
  Cancer Immunology Research
  Availale from: https://dx.doi.org/10.1007%2Fs00262-016-1864-z
  
  
• Expanded and activated natural killer cells for immunotherapy of hepatocellular carcinoma (2016)
  Kamiya T, Chang YH, Campana D. 
  Cancer Immunology Research
  Available from: https://doi.org/10.1158/2326-6066.cir-15-0229

2015

• A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing (2015)
  Prapa M, Caldrer S, Spano C, Bestagno M, Golinelli G, Grisendi G, Petrachi T, Campana D, Paolucci P, Dominici M. 
  Oncotarget
  Available from: https://doi.org/10.18632/oncotarget.4670
  
  
• 4-1BB chimeric antigen receptors (2015)
  Campana D, Schwarz H, Imai C. 
  Cancer Journal
  Available from: https://doi.org/10.1097/ppo.0000000000000028
  
  
• Chimeric antigen receptor technology: a breakthrough in immuno-oncology (2015)
  Campana D. 
  Medicographia
  Available from: https://www.medicographia.com/2016/04/chimeric-antigen-receptor-technology-a-breakthrough-in-immuno-oncology/
  
  

2014

• T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing (2014)
  Kudo K, Imai C, Lorenzini P, Kamiya T, Kono K, Davidoff AM, Chng WJ, Campana D. 
  Cancer Research
  Available from: https://doi.org/10.1158/0008-5472.can-13-1365
  
  
• Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer (2014)
  Mimura K, Kamiya T, Shiraishi K, Kua LF, Shabbir A, So J, Yong WP, Suzuki Y, Yoshimito Y, Nakano T, Fujii H, Campana D, Kono K. International Journal of Cancer
  Available from: https://doi.org/10.1002/ijc.28780
  
  
• Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15 (2014)
  Imamura M, Shook D, Kamiya T, Shimasaki N, Chai S, Coustan-Smith E, Imai C, Campana D.
  Blood
  Available from: https://doi.org/10.1182/blood-2014-02-556837

2013

• A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells (2013)
  Chang YH, Connolly J, Shimasaki N, Mimura K, Kono K, Campana D.
  Cancer Research
  Available from: https://doi.org/10.1158/0008-5472.can-12-3558
  
  
• A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus (2013)
  Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, Soh AMO, Gehring AJ, Stauss H, Renia L, Sällberg M, Campana D, Bertoletti A.
  Molecular Therapy (Nucleic Acids)
  Available from: https://doi.org/10.1038/mtna.2013.43

VIVA-Goh Foundation Professorship in Paediatric Oncology

2019

• Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
  Vijayakrishnan J, Qian M, Studd JB, Yang W, Kinnersley B, Law PJ, Broderick P, Raetz EA, Allan J, Pui CH, Vora A, Evans WE, Moorman A, Yeoh A, Yang W, Li C, Bartram CR, Mullighan CG, Zimmerman M, Hunger SP, Schrappe M, Relling MV, Stanulla M, Loh ML, Houlston RS, Yang JJ.
  Nature Communications
  Available from: https://doi.org/10.1038/s41467-019-13069-6
  
  
• Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1
  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG . Leukemia
  Available from: https://doi.org/10.1038/s41375-019-0413-0

• Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial
  Rubnitz JE, Lacayo NJ, Inaba H, Heym K, Ribeiro RC, Taub J, McNeer J, Degar B, Schiff D, Yeoh AE, Coustan-Smith E, Wang L, Triplett B, Raimondi SC, Klco J, Choi J, Pounds S, Pui CH
  Journal of Clinical Oncology
  Available from: https://doi.org/10.1200/jco.19.00327
  
  

• Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update
  Relling M, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui C-H, Stein CM, Moyer AM, Evans WE, Klein TE, Guillermo Antillon-Klussmann F, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.
  Clinical Pharmacology & Therapeutics 
  Available from: https://doi.org/10.1002/cpt.1304
  
  

• The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia
  Tan SH, Leong WZ, Ngoc PCT, Tan TK, Bertulfo FC, Lim MC, An O, Li Z, Yeoh AEJ, Fullwood MJ, Tenen DG, Sanda T.
  Blood
  Available from: https://doi.org/10.1182/blood.2018874503
  
  
• Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study
  Pui CH, Rebora P, Schrappe M, Attarbaschi A, Baruchel A, Basso G, Cavé H, Elitzur S, Koh K, Liu HC, Paulsson K, Pieters R, Silverman LB, Stary J, Vora A, Yeoh A, Harrison CJ, Valsecchi MG; Ponte di Legno Childhood ALL Working Group
  Journal of Clinical Oncology
  Available from: https://doi.org/10.1200/jco.18.00822
  

• Genomic subtyping and therapeutic targeting of acute erythroleukemia
  Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
  Nature Genetica
  Available from: https://doi.org/10.1038/s41588-019-0375-1
  
  

2018

• Clonality and clonal evolution analysis of paediatric ALL based on B-cell receptor/T-cell receptor rearrangement
  Ding LW, Tan KT, Sun QY, Lao ZT, Yang H, Jiang N, Chien W, Xiao JF, Loh XY, Huang ML, Lill M, Lin DC, Yeoh AEJ, Koeffler HP.
  British Journal of Haematology 
  Available from: https://doi.org/10.1111/bjh.15179
  
  

• Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. Leukemia
  Studd JB, Yang M, Li Z, Vijayakrishnan J, Lu Y, Yeoh AE, Paulsson K, Houlston RS
  Leukaemia
  Available from: http://doi.org/10.1038/s41375-018-0184-z
  
  
• Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases
  Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY.
  Proceedings of the Natural Academy of Sciences of the United States of America
  Available from: https://doi.org/10.1073/pnas.1814397115
  
  
• Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia
  Thi Ngoc PC, Tan SH, Tan TK, Chan MM, Li Z, Yeoh AEJ, Tenen DG, Sanda T
  Leukaemia
  Available from: https://doi.org/10.1038/s41375-018-0110-4
  
  
• Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study (2018)
  Yeoh AEJ, Lu Y, Chin WHN, et al.
  Journal of Clinical Oncology
  Available from: https://doi.org/10.1200/jco.2018.78.3050
  
  
• Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling
  Yeoh AE, Li Z, Dong D, Lu Y, Jiang N, Trka J, Tan AM, Lin HP, Quah TC, Ariffin H, Wong L.
  British Journal of of Haematology
  Available from: https://doi.org/10.1111/bjh.15252
  
  
• Universal monitoring of minimal residual disease in acute myeloid leukemia (2018)
  Coustan-Smith E, Song G, Shurtleff S, et al. . 
  JCI Insight
  Available from: https://doi.org/10.1172/jci.insight.98561
  
  
• Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy
  Nishii R, Moriyama T, Janke LJ, Yang W, Suiter C, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Koh K, Yeoh AE, Hori H, Yang JJ
  Blood
  Available from: https://dx.doi.org/10.1182/blood-2017-11-815506