2 Oct 2020 Hero Image

Current Concepts in the Biology and  Treatment of Langerhans Cell Histiocytosis (LCH)

Friday, 2 Oct 2020
08:30 (Singapore UTC+8)



The VIVA Asia Education Webinar Series brings together regional delegates from developing countries to discuss treatment, data management, and evaluation of outcomes for paediatric solid tumours and leukaemia. This Webinar Series continues the educational opportunities offered by the VIVA Asia Educational Day, which evolved from the pre-forum workshop at the annual St. Jude-VIVA Forum in Paediatric Oncology.

In this webinar, Dr Carlos Rodriguez-Galindo (St Jude Children's Research Hospital) will expound on the latest research on Langerhans Cell Histiocytosis (LCH). LCH is caused by clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ involvement and dysfunction. The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway. Treatment of LCH is risk-adapted; patients with single lesions may respond well to local treatment, whereas patients with multi-system disease require systemic therapy. While survival for patients without organ dysfunction is excellent, mortality rates for patients with organ dysfunction may reach 20%.

Despite progress made in the treatment of LCH, disease reactivation rates remain above 30%, and standard second-line treatment is yet to be established. Treatment failure is associated with increased risks of death and long-term morbidity, including LCH-associated neurodegeneration. Early case series report promising clinical responses in patients with relapsed and refractory LCH treated with BRAF or MEK inhibitors, although potential for this strategy to achieve cure remains uncertain.

Certificates of Attendance will be issued upon successful compliance with VIVA's Attendance Policy.





TC Quah


Dr Carlos Rodriguez-Galindo

Member, St. Jude Faculty
Executive Vice President
Chair, Department of Global Pediatric Medicine
Director, St. Jude Global
Associate Director, Outreach, Comprehensive Cancer Center
St Jude Children's Research Hospital

Dr Rodriguez-Galindo's clinical research focuses on the development of innovative therapies for pediatric solid tumors, in particular retinoblastoma, sarcomas, and rare cancers. He is the principal investigator of multi-institutional trials on childhood nasopharyngeal carcinoma, adrenocortical carcinoma, Langerhans cell histiocytosis, and recurrent germ cell tumors at the Children’s Oncology Group, where he currently serve as Chair of the Rare Tumors Committee.

He has also been the Medical Director of the Clinical and Translational Investigations Program (CTIP) at the Dana-Farber/Children’s Hospital Cancer and Blood Disorders Center, a position that he held between 2009 and 2015, before moving to St. Jude Children’s Research Hospital. He believes that work in pediatric oncology is not complete without considering the less fortunate, and has been involved in the development of pediatric oncology programs in countries with limited resources.

He is the Chair of the Department of Global pediatric Medicine and Director of the International Outreach Program at St. Jude Children’s Research Hospital. The program integrates program building, research and education as we develop new models for intervention to improve outcome for those children with cancer and blood disorders in countries with limited resources.

TC Quah


Assoc Prof TC Quah

Senior Consultant, Division of Paediatric Haematology and Oncology, Department of Paediatrics
Khoo Teck Puat - National University Children's Medical Institute
National University Hospital
Associate Professor, Department of Paediatrics, Yong Loo Lin School of Medicine
National University of Singapore

Associate Professor Quah Thuan Chong grew up in the island of Penang (a beautiful city off the western coast of West Malaysia) and came to another island (another beautiful island off the southern coast of West Malaysia) in 1971 to study medicine at the then University of Singapore.

He was captivated and inspired by Professor Wong Hock Boon, the "walking encyclopaedia" and "the smartest man I've ever known personally" whose motto is "if you want to do paediatrics, you've got to live paediatrics, eat paediatrics, sleep paediatrics". He was also inspired by the children he got to know when he was doing his housemanship (internship) in 1976 in the University Department of Paediatrics (then at the Mistri Wing in the Singapore General Hospital).

Then and there, he decided to spend the rest of his life looking after kids. After spending a very happy one year in the paediatric department in Alexandra Hospital under another wonderful mentor, Dr Tan Keng Wee, he went back to the University's Department of Paediatrics, and has been there ever since (moving together with the department to the National University Hospital in 1986).

He is the recipient of the National Medical Excellence Awards 2013 (National Outstanding Clinician Mentor Award).

Michelle Hermiston


Dr Michelle Hermiston

Associate Professor of Pediatrics
Pediatric Haematologist-Oncologist
University of California San Francisco Benioff Children’s Hospital
Director, Immunotherapy Program

Dr. Michelle L. Hermiston is a specialist in pediatric cancer and blood diseases at UCSF Benioff Children's Hospital with a special interest in defining the underlying mechanisms in the development of lymphoid malignancies, including leukemia and lymphoma. She earned a medical degree and doctorate in developmental biology at Washington University School of Medicine and the Division of Biology and Biomedical Sciences. She completed a fellowship in pediatric hematology and oncology and a residency at UCSF before joining the faculty in 2002. She also participated in a medical scientist training program at Washington University and at the UCSF Molecular Medicine Research Fellowship Program. She is a member of numerous organizations, including the American Society of Hematology and American Academy of Pediatrics. Hermiston is an assistant professor of pediatric hematology and oncology at the University of California, San Francisco.

TC Quah


Dr Frances Yeap

Consultant, Division of Paediatric Haematology and Oncology
Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute
National University Hospital

Dr Yeap graduated from St Bartholomew’s and The Royal London School of Medicine and Dentistry and returned to Singapore to work and train in Paediatrics. Her clinical practice involves General Paediatrics and all aspects of Paediatric Haematology and Oncology, including Bone Marrow Transplant. She has a special interest in the area of bone marrow transplants, especially that of non-malignant transplants and immunodeficiencies.